找到约 55 条 “NT 13” 相关结果 （用时 0.051 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M25536
|
Recombinant Human CXCL13/BCA-1 (E. coli) | 重组人CXCL13/BCA-1蛋白 (E. coli) | Recombinant Proteins |
| CXC chemokine BLC; Small-inducible cytokine B13 | |||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | |||
| M25587
|
Recombinant Mouse CXCL13/BCA-1 Protein (HEK293, N-Fc) | 重组小鼠CXCL13/BCA-1蛋白 (HEK293, N-Fc) | Recombinant Proteins |
| CXCL13 is a homeostatic chemokine, and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles). Recombinant Mouse CXCL13/BCA-1 Protein is produced by HEK293 expression system with a N-Terminal Fc-tag. | |||
| M9982
|
Recombinant Human IL-13 Protein (HEK293, C-His) | 重组人IL-13蛋白 (HEK293, C-His) | Recombinant Proteins |
| Interleukin-13; rhIL-13 | |||
| 重组人IL-13蛋白（Recombinant Human IL-13 Protein）是一种免疫调节细胞因子，主要由活化的Th2细胞、肥大细胞和NK细胞产生。 | |||
| M10229
|
Porcine dynorphin A (1-13) | 强啡肽A(1-13),猪 | Opioid Receptor |
| Dynorphin A Porcine Fragment 1-13 | |||
| Porcine dynorphin A (1-13) 是一个有效的内源性阿片受体 (κ opioid receptor) 激动剂。 | |||
| M11197
|
Recombinant Mouse IL-13 Protein (CHO, His) | 重组小鼠IL-13蛋白(CHO, His) | Recombinant Proteins |
| rMuIL-13, His; P600 | |||
| 重组小鼠IL-13蛋白 (CHO, His) 是一种 CHO 细胞来源的重要细胞因子，是一种多功能细胞因子，其主要作用是减少炎症反应。 | |||
| M11388
|
Anti-human CD137 mAb | 抗人CD137单克隆抗体（GMP级） | Recombinant Proteins |
| 生物活性：CD137(也称作 4-1BB)，CD137是一种可诱导的细胞表面受体，属于肿瘤坏死因子受体( tumornecrosis factor receptor, TNFR)超家族成员。 | |||
| M11569 | ChemBridge-4013929 | ChemBridge化合物-4013929 | Screening Compounds and Building Blocks |
| 1-adamantylacetic acid (4013929) | |||
| ChemBridge特有类药化合物/先导化合物-4013929，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11579 | ChemBridge-4141340 | ChemBridge化合物-4141340 | Screening Compounds and Building Blocks |
| 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid (4141340) | |||
| ChemBridge特有类药化合物/先导化合物-4141340，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11581 | ChemBridge-5100275 | ChemBridge化合物-5100275 | Screening Compounds and Building Blocks |
| pentacyclo[6.6.6.0~2,7~.0~9,14~.0~15,20~]icosa-2(7),4,9,11,13,15,17,19-octaene-3,6-dione (5100275) | |||
| ChemBridge特有类药化合物/先导化合物-5100275，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11673 | ChemBridge-5134246 | ChemBridge化合物-5134246 | Screening Compounds and Building Blocks |
| 1-hydroxyanthra-9,10-quinone (5134246) | |||
| ChemBridge特有类药化合物/先导化合物-5134246，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11674 | ChemBridge-5135283 | ChemBridge化合物-5135283 | Screening Compounds and Building Blocks |
| 4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid hydrochloride trihydrate (5135283) | |||
| ChemBridge特有类药化合物/先导化合物-5135283，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11676 | ChemBridge-5135600 | ChemBridge化合物-5135600 | Screening Compounds and Building Blocks |
| 9,10-dioxo-N-phenyl-9,10-dihydro-2-anthracenesulfonamide (5135600) | |||
| ChemBridge特有类药化合物/先导化合物-5135600，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11683 | ChemBridge-5137132 | ChemBridge化合物-5137132 | Screening Compounds and Building Blocks |
| 2,6,7-trihydroxy-9-(2-hydroxyphenyl)-3H-xanthen-3-one (5137132) | |||
| ChemBridge特有类药化合物/先导化合物-5137132，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11684 | ChemBridge-5137877 | ChemBridge化合物-5137877 | Screening Compounds and Building Blocks |
| 8-cyclopentyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole methanesulfonate (5137877) | |||
| ChemBridge特有类药化合物/先导化合物-5137877，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11687 | ChemBridge-5138859 | ChemBridge化合物-5138859 | Screening Compounds and Building Blocks |
| (1-{1-[1-tert-butyl-3-(2,4-dichlorophenyl)-2-propen-1-yl]-1H-tetrazol-5-yl}cyclopentyl)(4-chlorophenyl)amine (5138859) | |||
| ChemBridge特有类药化合物/先导化合物-5138859，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11825 | ChemBridge-5213336 | ChemBridge化合物-5213336 | Screening Compounds and Building Blocks |
| 8-(3-pyridinyl)-8,10,11,12-tetrahydrobenzo[a]-4,7-phenanthrolin-9(7H)-one (5213336) | |||
| ChemBridge特有类药化合物/先导化合物-5213336，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11827 | ChemBridge-5213626 | ChemBridge化合物-5213626 | Screening Compounds and Building Blocks |
| 5-[4-(diethylamino)phenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one (5213626) | |||
| ChemBridge特有类药化合物/先导化合物-5213626，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11828 | ChemBridge-5213651 | ChemBridge化合物-5213651 | Screening Compounds and Building Blocks |
| 5-[4-(dimethylamino)phenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one (5213651) | |||
| ChemBridge特有类药化合物/先导化合物-5213651，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11829 | ChemBridge-5213684 | ChemBridge化合物-5213684 | Screening Compounds and Building Blocks |
| 5-(5-bromo-2-hydroxyphenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one (5213684) | |||
| ChemBridge特有类药化合物/先导化合物-5213684，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12106 | ChemBridge-5491327 | ChemBridge化合物-5491327 | Screening Compounds and Building Blocks |
| 5-(4-isopropylphenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one (5491327) | |||
| ChemBridge特有类药化合物/先导化合物-5491327，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12133 | ChemBridge-5541353 | ChemBridge化合物-5541353 | Screening Compounds and Building Blocks |
| 1-(1-adamantylcarbonyl)-1,2,3,4-tetrahydroquinoline (5541353) | |||
| ChemBridge特有类药化合物/先导化合物-5541353，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12784 | ChemBridge-6813327 | ChemBridge化合物-6813327 | Screening Compounds and Building Blocks |
| 5-[3'-(4-methylphenyl)-1'-phenyl-5-(2-thienyl)-3,4-dihydro-1'H,2H-3,4'-bipyrazol-2-yl]-5-oxopentanoic acid (6813327) | |||
| ChemBridge特有类药化合物/先导化合物-6813327，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M13256 | ChemBridge-19139800 | ChemBridge化合物-19139800 | Screening Compounds and Building Blocks |
| 3-({[(1-cyclopentyl-3-piperidinyl)methyl][2-(1-piperidinyl)ethyl]amino}methyl)phenol (19139800) | |||
| ChemBridge特有类药化合物/先导化合物-19139800，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M14561
|
Recombinant Human MIP-5/CCL15 Protein (E. coli, aa 22-113, C-His) | 重组人MIP-5/CCL15蛋白 (E. coli, aa 22-113, C-His) | Recombinant Proteins |
| SCYA15; HCC-2; NCC-3 | |||
| Chemokine ligand 15 (CCL15), also known as leukotactin-1, MIP5, MIP1 and HCC-2, is a small cytokine belonging to the C-C chemokine family. CCL15 is prevantly expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. | |||
| M16343 | ent-Labda-8(17),13-dien-16,15-olid- 19-oic acid glucosyl ester | ent-Labda-8(17),13-dien-16,15-olid- 19-oic acid glucosyl ester | Diterpenoids |
| ent-Labda-8(17),13-dien-16,15-olid- 19-oic acid glucosyl ester | |||
| M16344 | ent-11α-Hydroxyabieta- 8(14),13(15)-dien-16,12α-olide | ent-11α-Hydroxyabieta- 8(14),13(15)-dien-16,12α-olide | Diterpenoids |
| ent-11α-Hydroxyabieta- 8(14),13(15)-dien-16,12α-olide | |||
| M16354 | ent-13,16β,17-Trihydroxykauran-19-oic acid | ent-13,16β,17-Trihydroxykauran-19-oic acid | Diterpenoids |
| ent-13,16β,17-Trihydroxykauran-19-oic acid | |||
| M16355 | ent-Labda-8(17),13E-diene-3β,15,18-triol | ent-Labda-8(17),13E-diene-3β,15,18-triol | Diterpenoids |
| ent-Labda-8(17),13E-diene-3β,15,18-triol | |||
| M21345
|
Recombinant Human CXCL16 (Pro49-Pro137) (E.coli) | 重组人CXCL16 (Pro49-Pro137) 蛋白 (E.coli) | Recombinant Proteins |
| SR-PSOX，Small-inducible cytokine B16 | |||
| 蛋白构造：编码人类CXCL16（Pro49-Pro137）的DNA序列与GST标签融合。Accession #：Q9H2A7。 | |||
| M21664
|
Recombinant Human F13A (Mammalian, C-6His) | 重组人凝血因子 XIII A 链蛋白 (Mammalian, C-6His) | Recombinant Proteins |
| Coagulation Factor XIII A Chain | |||
| 重组人凝血因子 XIII A 链 (F13A) 由哺乳动物表达系统产生，编码 Gly39-Met732 的靶基因在 C 端用 6His 标签表达。凝血因子 XIII 是凝血级联反应中最后激活的酶原。血浆因子 XIII 是由 2 个 A 亚基和 2 个 B 亚基组成的异四聚体。A亚基具有催化功能，B亚基不具有酶活性。 | |||
| M1673
|
Nintedanib (BIBF1120) | 尼达尼布 | VEGFR/PDGFR |
| Nintedanib | |||
| Nintedanib (BIBF 1120) 是一种有效的三重血管激酶抑制剂，对VEGFR1/2/3， FGFR1/2/3和PDGFRα/β均有抑制作用，其IC50分别为34 nM/13 nM/13 nM， 69 nM/37 nM/108 nM和59 nM/65 nM，可用于特发性肺纤维化（IPF）的相关研究。 | |||
| M2608
|
Kobe0065 | Kobe0065 | Ras |
| Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD, exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM. | |||
| M2981
|
Rimonabant | 利莫那班 | Cannabinoid |
| SR141716 | |||
| Rimonabant是一个大脑中心大麻素受体（CB1）特异性口服拮抗剂。在hCB1转染HEK293细胞中IC50浓度为13.6 nM，EC50浓度为17.3 nM。 | |||
M3261
|
Almorexant | 阿莫伦特 | OX Receptor |
| ACT-078573 | |||
| Almorexant是一种竞争性OX1和OX2促食素受体拮抗剂，IC50分别为13和8 nM。 | |||
| M6673
|
DIM-C-pPhOH | DIM-C-pPhOH | Apoptosis |
| DIM-C-pPhOH is a nur77 antagonist. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively. | |||
| M6835
|
IQ 1 | IQ 1 | Wnt/beta-catenin |
| IQ 1是一种 p300/β-catenin相互作用抑制剂，能通过增强 β-catenin/CBP 介导的转录并防止转换到 β-catenin/p300 介导的转录，从而维持 Wnt3a 处理细胞中胚胎干细胞（ESC）的多能性，以及防止自发分化。此外，IQ 1也能通过与 PR72/130 的相互作用调节 Wnt 信号传导。可用于 ESCs 扩增的研究。 | |||
| M7330
|
Meclinertant | Meclinertant | Neurotensin Receptor |
| SR 48692 | |||
| Meclinertant (SR 48692) 是一种有效的，选择性的，非肽和口服活性神经降压素受体 (NTS1) 拮抗剂。在人结肠癌细胞中，Meclinertant 竞争性拮抗神经降压素诱导的细胞内 Ca2+ 动员，pA2 值为 8.13。Meclinertant 具有抗焦虑，抗上瘾和记忆障碍的作用。 | |||
| M7554
|
Fruquintinib | 呋喹替尼 | VEGFR/PDGFR |
| HMPL-013 | |||
| Fruquintinib (HMPL-013) 是有效，选择性的 VEGFR 1/2/3 抑制剂，IC50 值分别为33，0.5 和 35 nM。同时，Fruquintinib能通过抑制血管内皮细胞表面的VEGFR磷酸化及下游信号转导，抑制血管内皮细胞的增殖、迁移和管腔形成，从而抑制肿瘤新生血管的形成，最终发挥肿瘤生长抑制效应。可用于结直肠癌的相关研究。 | |||
| M8448 | Thiophene-2 | Thiophene-2 | Others |
| Thiophene-2 (TP2) is an inhibitor of polyketide synthase 13 (Pks13), which plays a critical role in the biosynthesis of mycolic acid, an essential component of the cell wall in M. | |||
| M8456 | Thiophene-4 | Thiophene-4 | Others |
| Thiophene-4 (TP4) is an inhibitor of polyketide synthase 13 (Pks13), which plays a critical role in the biosynthesis of mycolic acid, an essential component of the cell wall in M. | |||
| M8576 | LP-211 | LP-211 | Others |
| LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0. | |||
| M8732
|
T-26c | T-26c | MMP |
| T-26c is a highly potent, selective and cell-permeable matrix metalloproteinases 13 (MMP-13) inhibitor. | |||
| M40806
|
Anti-Mouse NK1.1 In vivo | Anti-Mouse NK1.1 In vivo | Others |
| This NK1.1 antibody (clone PK136) recognizes mouse NK1.1. NK1.1 is a type II membrane protein that is part of the C-type lectin superfamily. | |||
| M9994
|
Recombinant Human IGF-1 LR3 Protein (HEK293) | 重组人IGF-1 LR3蛋白 (HEK293) | Recombinant Proteins |
| Long R3 IGF-1 | |||
| 重组人IGF-1 LR3蛋白（Recombinant Human IGF-1 LR3 Protein）是人IGF-Ⅰ的重组类似物，由完整的IGF-I序列组成，第三位谷氨酸有精氨酸替代，N端肽延伸13个氨基酸。专为更高的生物学效能而设计的离体IGF-ILR 3的半衰期增加，对体内天然蛋白质的结合厌恶，使其成为研究和大规模培养的理想选择。 | |||
| M10891 | Taranabant | Taranabant | Others |
| MK-0364 | |||
| Taranabant 是一种有效的选择性的 cannabinoid 1 (CB1) 受体反向激动剂，抑制结合和多种激动剂的功能活性，作用于人 CB1R，Ki 为 0.13 nM。 | |||
| M11390
|
Recombinant Human 4-1BB Protein (HEK293) | 重组人4-1BB蛋白 (HEK293) | Recombinant Proteins |
| TNFRSF9、4-1BB、CD137、CDw137、ILA | |||
| Recombinant Human 4-1BB Protein (HEK293) 蛋白序列：DNA 序列编码人 4-1BB（ UniProtKB/Swiss-Prot: Q07011.1）表达带有 His 标签在 C 末端 生物活性：4-1BB 又称 CD137，是由淋巴细胞活化（ILA）诱导的肿瘤坏死因子受体超家族成员 9（TNFRSF9），是肿瘤坏死因子（TNF）受体超家族的共刺激分子。 | |||
| M11555
|
Relacorilant | Relacorilant | GCR |
| CORT 125134 | |||
| Relacorilant（CORT 125134）是一种选择性的、具有口服活性的、有效的糖皮质激素受体（GR）拮抗剂，可以增加肿瘤微环境中NK和其他免疫细胞的丰度和功能，同时能促进具有糖皮质激素过量产生（GC+）情况的恶性肿瘤中的免疫反应，可用于库欣综合征（Cushing Syndrome，CS）和肿瘤（如肾上腺皮质癌）的相关研究。此外，Relacorilant在体外还可以抑制CYP3A4、CYP2C8和CYP2C9的活性，在体内也是一种有效的CYP3A抑制剂。 | |||
| M13642 | CX-5461 dihydrochloride | CX-5461 dihydrochloride | DNA/RNA Synthesis |
| CX-5461 dihydrochloride 是一种有效的，可口服的 Pol I 介导的 rRNA synthesis 抑制剂，在 HCT-116，A375 和 MIA PaCa-2 细胞中，IC50 值分别为 142 nM，113 nM 和 54 nM，对 Pol II 作用不大 (IC50 ≥25 μM)。 | |||
| M13956
|
Aprocitentan | Aprocitentan | Endothelin Receptor |
| ACT-132577 | |||
| Aprocitentan (ACT-132577) 是 Macitentan 的主要活性代谢物，同时也是一种具有口服活性的双重 ETA/ETB 拮抗剂，IC50 分别为 3.4 nM 和 987 nM，pA2 值分别为 6.7 和 5.5。可用于难治性高血压的相关研究。 | |||
| M14454
|
Mutant IDH1-IN-1 | Mutant IDH1-IN-1 | Isocitrate Dehydrogenase (IDH) |
| Mutant IDH1-IN-1是 IDH1 突变体的选择性抑制剂，对突变体IDH1 R132C/R132C，IDH1 R132H/R132H，IDH1 R132H/WT和野生型IDH1的 IC50 值分别为4, 42, 80 和 143 nM。 | |||
| M14456
|
Mutant IDH1 inhibitor | Mutant IDH1 inhibitor | Isocitrate Dehydrogenase (IDH) |
| Mutant IDH1 inhibitor 是一个有效的突变型 IDH1 R132H 的抑制剂，IC50 值小于 72 nM。 | |||
| M19867
|
Gatifloxacin hydrochloride | Gatifloxacin hydrochloride | Topoisomerase |
| AM-1155 hydrochloride; CG5501 hydrochloride; BMS-206584 hydrochloride; PD135432 hydrochloride | |||
| Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively. | |||
| M20515 | Emedastine | Emedastine | Histamine Receptor |
| Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM). | |||
| M20690 | FT113 | FT113 | FAS |
| FT113 is a potent inhibitor of fatty acid synthase(FASN) with ic50 of 213 nM. | |||
| M20724
|
RCM-1 | RCM-1 | IL Receptor/Related |
| Robert Costa Memorial drug-1 | |||
| RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin. | |||
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